GARP&Latent TGF beta Complex, Mouse (Biotinylated, HEK293, His-Avi)
Product Specifications
UNSPSC Description
GARP/latent TGF-b1 complexes are potent inducers of Th17 differentiation in the presence of exogenous IL-6 and inducers of Treg in the presence of IL-2. GARP&Latent TGF beta Complex Protein, Mouse (Biotinylated, HEK293, His-Avi) is a biotinylated recombinant protein (GARP (I18-N628)&TGF-b1 (L30-S390)) produced by HEK293 cells with His-Avi tag[1][2].
Type
Recombinant Proteins
Assay Protocol
https://www.medchemexpress.com/cytokines/garp-latent-tgf-beta-complex-protein-mouse-biotinylated-hek293-his-avi.html
Molecular Weight
72-76 kDa
References & Citations
[1]Soyoung A Oh,TGF-β: guardian of T cell function. J Immunol. 2013 Oct 15;191(8):3973-9.|[2]Angela X Zhou, et al. GARP-TGF-β complexes negatively regulate regulatory T cell development and maintenance of peripheral CD4+ T cells in vivo. J Immunol. 2013 May 15;190(10):5057-64.|[3]Justin P Edwards, et al. The GARP/Latent TGF-β1 complex on Treg cells modulates the induction of peripherally derived Treg cells during oral tolerance. Eur J Immunol. 2016 Jun;46(6):1480-9.
Shipping Conditions
Room temperature
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