Dendrogenin A

Dendrogenin A (DDA) is a ligand for liver X receptor (LXR), that induces the expression of sodium/iodine symporter, and increases iodine uptake. Dendrogenin A induces cell differentiation of MCF-7, and reactivates the function of lactating cells. Dendrogenin A induces the expressions of the TSH receptor, thyroid peroxidase, and thyroglobulin, and affects thyroid hormone generation. Dendrogenin A exhibits cytotoxicity in cancer cell B-CPAP and 8505c with IC50 of 4.1 and 6.2 µM. Dendrogenin A arrests the cell cycle at G0/G1 phase[1].

Product Specifications

CAS Number

[1191043-85-2]

Product Name Alternative

DDA

UNSPSC

12352200

Target

LXR

Type

Biochemical Assay Reagents

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dendrogenin-a.html

Purity

96.7

Solubility

DMSO : 30 mg/mL (ultrasonic; warming)

Smiles

C[C@@]12[C@]3([H])[C@](C[C@H]([C@]1(C[C@H](CC2)O)O)NCCC4=CN=CN4)([H])[C@@]5([H])[C@](CC3)([C@@](CC5)([H])[C@H](C)CCCC(C)C)C

Molecular Formula

C32H55N3O2

Molecular Weight

513.80

References & Citations

[1]Bauriaud-Mallet M, et al., The cholesterol-derived metabolite dendrogenin A functionally reprograms breast adenocarcinoma and undifferentiated thyroid cancer cells. J Steroid Biochem Mol Biol. 2019 Sep;192:105390.