RYK Antibody [AMM07703G]
Product Specifications
Background
Tissue Location: Observed in all the tissues examined.
Synonyms
Tyrosine-protein kinase RYK, 2.7.10.1, RYK, JTK5A
Gene Name
HGNC:10481
Gene ID
6259
UniProt
P34925
Chromosomal Location
Membrane; Single-pass type I membrane protein. Nucleus. Cytoplasm. Note=In cells that have undergone neuronal differentiation, the C-terminal cleaved part is translocated from the cytoplasm to the nucleus.
Applications
WB, FC
Dilution
FC--1:25 WB--1:1000
Function
May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C-terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development.
Molecular Weight
67815
Storage Conditions
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality RYK Antibody [AMM07703G].
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=6259
Uniprot URL
https://www.uniprot.org/uniprot/P34925
Available Sizes
Curated Selection
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