AZD6538

AZD6538 is a potent, selective and brain penetrant mGluR5 negative allosteric modulator. AZD6538 inhibits DHPG (HY-12598A) -stimulated intracellular Ca2+ release in HEK cells expressing rat or human mGluR5, with IC50 values of 3.2 and 13.4 nM for rat mGluR5 and human mGluR5, respectively. AZD6538 can be used for the research of neuropathic pain[1].

Product Specifications

CAS Number

[453566-30-8]

UNSPSC

12352005

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/azd6538.html

Purity

99.21

Solubility

DMSO : 4 mg/mL (ultrasonic;warming;heat to 60°C)

Smiles

N#CC1=CC=C(N=C1)C2=NOC(C3=CC(F)=CC(C#N)=C3)=N2

Molecular Formula

C15H6FN5O

Molecular Weight

291.24

References & Citations

[1]Raboisson P, et al. Discovery and characterization of AZD9272 and AZD6538-Two novel mGluR5 negative allosteric modulators selected for clinical development. Bioorg Med Chem Lett. 2012 Nov 15;22 (22) :6974-9.