Ivachtin

Ivachtin (Caspase-3 Inhibitor VII; compound 7a) is a nonpeptide, noncompetitive and reversibl caspase-3 inhibitor with an IC50 of 23 nM. Ivachtin has modest selectivity for the remaining caspases[1].

Product Specifications

CAS Number

[745046-84-8]

Product Name Alternative

Caspase-3 Inhibitor VII

UNSPSC

12352005

Target

Caspase

Type

Reference compound

Related Pathways

Apoptosis

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/ivachtin.html

Purity

99.71

Solubility

DMSO : ≥ 10 mg/mL

Smiles

O=C1N(CCOC(C)=O)C(C2=C1C3=CC(S(=O)(N4CCOCC4)=O)=CC=C3N=C2C)=O

Molecular Formula

C20H21N3O7S

Molecular Weight

447.46

References & Citations

[1]Kravchenko DV, et al. Synthesis and structure-activity relationship of 4-substituted 2- (2-acetyloxyethyl) -8- (morpholine-4-sulfonyl) pyrrolo[3,4-c]quinoline-1,3-diones as potent caspase-3 inhibitors. J Med Chem. 2005 Jun 2;48 (11) :3680-3.