Ivachtin
Product Specifications
UNSPSC Description
Ivachtin (Caspase-3 Inhibitor VII; compound 7a) is a nonpeptide, noncompetitive and reversibl caspase-3 inhibitor with an IC50 of 23 nM. Ivachtin has modest selectivity for the remaining caspases[1].
Target Antigen
Caspase
Type
Reference compound
Related Pathways
Apoptosis
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ivachtin.html
Purity
99.71
Solubility
DMSO : ≥ 10 mg/mL
Smiles
O=C1N(CCOC(C)=O)C(C2=C1C3=CC(S(=O)(N4CCOCC4)=O)=CC=C3N=C2C)=O
Molecular Weight
447.46
References & Citations
[1]Kravchenko DV, et al. Synthesis and structure-activity relationship of 4-substituted 2-(2-acetyloxyethyl)-8-(morpholine-4-sulfonyl)pyrrolo[3,4-c]quinoline-1,3-diones as potent caspase-3 inhibitors. J Med Chem. 2005 Jun 2;48(11):3680-3.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P1095/Ivachtin-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P1095/Ivachtin-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
745046-84-8
Available Sizes
Curated Selection
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