Ivachtin
Ivachtin (Caspase-3 Inhibitor VII; compound 7a) is a nonpeptide, noncompetitive and reversibl caspase-3 inhibitor with an IC50 of 23 nM. Ivachtin has modest selectivity for the remaining caspases[1].
Product Specifications
CAS Number
[745046-84-8]
Product Name Alternative
Caspase-3 Inhibitor VII
UNSPSC
12352005
Target
Caspase
Type
Reference compound
Related Pathways
Apoptosis
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ivachtin.html
Purity
99.71
Solubility
DMSO : ≥ 10 mg/mL
Smiles
O=C1N(CCOC(C)=O)C(C2=C1C3=CC(S(=O)(N4CCOCC4)=O)=CC=C3N=C2C)=O
Molecular Formula
C20H21N3O7S
Molecular Weight
447.46
References & Citations
[1]Kravchenko DV, et al. Synthesis and structure-activity relationship of 4-substituted 2- (2-acetyloxyethyl) -8- (morpholine-4-sulfonyl) pyrrolo[3,4-c]quinoline-1,3-diones as potent caspase-3 inhibitors. J Med Chem. 2005 Jun 2;48 (11) :3680-3.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Caspase 3
Available Sizes
Curated Selection
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