ACK1 Antibody (C-term) [APR05996G]
Product Specifications
Background
Tissue Location: The Tyr-284 phosphorylated form shows a significant increase in expression in breast cancers during the progressive stages i.e. normal to hyperplasia (ADH), ductal carcinoma in situ (DCIS), invasive ductal carcinoma (IDC) and lymph node metastatic (LNMM) stages. It also shows a significant increase in expression in prostate cancers during the progressive stages.
Synonyms
Activated CDC42 kinase 1, ACK-1, Tyrosine kinase non-receptor protein 2, TNK2, ACK1
Gene Name
TNK2
Gene ID
10188
UniProt
Q07912
Chromosomal Location
Cell membrane. Nucleus. Endosome {ECO:0000250|UniProtKB:O54967} Cell junction, adherens junction. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, clathrin-coated vesicle Membrane, clathrin-coated pit. Cytoplasm, perinuclear region. Cytoplasm, cytosol {ECO:0000250|UniProtKB:O54967}. Note=The Tyr-284 phosphorylated form is found both in the membrane and nucleus (By similarity) . Co-localizes with EGFR on endosomes (PubMed:20333297) . Nuclear translocation is CDC42-dependent (By similarity) . Detected in long filamentous cytosolic structures where it co-localizes with CTPS1 (By similarity) {ECO:0000250|UniProtKB:O54967, ECO:0000269|PubMed:20333297}
Applications
IHC-P, WB
Dilution
WB--1:1000 IHC-P--1:100~500
Form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Function
20110370
Molecular Weight
114569
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality ACK1 Antibody (C-term) [APR05996G].
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=10188
Uniprot URL
https://www.uniprot.org/uniprot/Q07912
Available Sizes
Curated Selection
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