MKRN1 Antibody (Center) [APR04460G]

Product Specifications

Background

Tissue Location: Ubiquitous.

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality MKRN1 Antibody (Center) [APR04460G].

Synonyms

E3 ubiquitin-protein ligase makorin-1, 632-, RING finger protein 61, MKRN1, RNF61

Gene Name

MKRN1

Gene ID

23608

UniProt

Q9UHC7

Applications

Dilution

WB--1:1000

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II- dependent transcription.