MKRN1 Antibody (Center) [APR04460G]
Product Specifications
Background
Tissue Location: Ubiquitous.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality MKRN1 Antibody (Center) [APR04460G].
Synonyms
E3 ubiquitin-protein ligase makorin-1, 632-, RING finger protein 61, MKRN1, RNF61
Gene Name
MKRN1
Gene ID
23608
UniProt
Q9UHC7
Applications
WB
Dilution
WB--1:1000
Form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Function
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II- dependent transcription.
Molecular Weight
53349
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=23608
Uniprot URL
https://www.uniprot.org/uniprot/Q9UHC7
Available Sizes
Curated Selection
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