Mouse Prr5 Antibody (C-term) [APR04423G]
Product Specifications
Background
Tissue Location: Ubiquitously expressed. Expressed at high levels in kidney.
Synonyms
Proline-rich protein 5, Protein observed with Rictor-1, Protor-1, Prr5 {ECO:0000250|UniProtKB:P85299}, Protor1
Gene Name
Prr5 {ECO:0000250|UniProtKB:P85299}
Gene ID
109270
UniProt
Q812A5
Applications
WB
Dilution
WB--1:1000
Form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Function
Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling. May act as a tumor suppressor in breast cancer (By similarity) .
Molecular Weight
42523
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Mouse Prr5 Antibody (C-term) [APR04423G].
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=109270
Uniprot URL
https://www.uniprot.org/uniprot/Q812A5
Available Sizes
Curated Selection
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