SENP6 Antibody (C-term) [APR03688G]
Product Specifications
Background
Tissue Location: Highly expressed in reproductive organs, such as testis, ovary and prostate
Synonyms
Sentrin-specific protease 6, SUMO-1-specific protease 1, Sentrin/SUMO-specific protease SENP6, SENP6, KIAA0797, SSP1, SUSP1
Gene Name
SENP6
Gene ID
26054
UniProt
Q9GZR1
Chromosomal Location
Nucleus
Applications
IHC-P, WB
Dilution
WB--1:1000 IHC-P--1:100 IHC-P--1:100~500
Form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Function
Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination.
Molecular Weight
126146
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality SENP6 Antibody (C-term) [APR03688G].
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=26054
Uniprot URL
https://www.uniprot.org/uniprot/Q9GZR1
Available Sizes
Curated Selection
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