ANGPT2 Antibody (C-term) [APR03419G]

Product Specifications

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality ANGPT2 Antibody (C-term) [APR03419G].

Synonyms

Angiopoietin-2, ANG-2, ANGPT2

Gene Name

ANGPT2

Gene ID

285

UniProt

O15123

Chromosomal Location

Secreted.

Applications

WB, FC

Dilution

WB--1:500 WB--1:1000 FC--1:25 IHC-P--1:100~500 WB--1:2000 FC--1:10~50

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.