EN171
Product Specifications
UNSPSC Description
EN171 is a covalent ligand that covalently targets both C38 and C96 on 14-3-3 to enhance 14-3-3 interactions with ERα, YAP and TAZ, leading to impaired estrogen receptor and Hippo pathway transcriptional activity. EN171 can not only be used as a molecular glue to enhance native protein interactions but can also be used as a covalent 14-3-3 recruiter in heterobifunctional molecules to sequester nuclear neo-substrates such as BRD4 and BLC6 into the cytosol[1].
Target Antigen
Others
Type
Reference compound
Related Pathways
Others
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/en171.html
Smiles
O=C(N1CCC2(CN(CC2)CC3=CC=CC=C3)C1)C=C
Molecular Weight
270.37
References & Citations
[1]Shao Q, et al. Targeted Protein Localization by Covalent 14-3-3 Recruitment. J Am Chem Soc. 2024 Sep 11;146(36):24788-24799.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-W1005067/EN171-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-W1005067/
Clinical Information
No Development Reported
CAS Number
2191110-79-7
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