EN171
EN171 is a covalent ligand that covalently targets both C38 and C96 on 14-3-3 to enhance 14-3-3 interactions with ERα, YAP and TAZ, leading to impaired estrogen receptor and Hippo pathway transcriptional activity. EN171 can not only be used as a molecular glue to enhance native protein interactions but can also be used as a covalent 14-3-3 recruiter in heterobifunctional molecules to sequester nuclear neo-substrates such as BRD4 and BLC6 into the cytosol[1].
Product Specifications
CAS Number
[2191110-79-7]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Estrogen Receptor/ERR; Hippo (MST) ; Molecular Glues
Type
Reference compound
Related Pathways
PROTAC; Stem Cell/Wnt; Vitamin D Related/Nuclear Receptor
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/en171.html
Purity
98.14
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C(N1CCC2(CN(CC2)CC3=CC=CC=C3)C1)C=C
Molecular Formula
C17H22N2O
Molecular Weight
270.37
Precautions
H302, H315, H319, H335
References & Citations
[1]Shao Q, et al. Targeted Protein Localization by Covalent 14-3-3 Recruitment. J Am Chem Soc. 2024 Sep 11;146 (36) :24788-24799.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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