Euptox A

Euptox A (9-Oxo-10, 11-dehydroageraphorone), a cadenine sesquiterpene, is the main toxin that can be isolated from Eupatorium adenophorum. Euptox A induces apoptosis by improving the gene expression level of apoptotic proteases such as caspase-10 in HeLa cells[1].

Product Specifications

CAS Number

[79491-71-7]

Product Name Alternative

9-Oxo-10,11-dehydroageraphorone

UNSPSC

12352211

Hazard Statement

H302-H315-H319-H335

Target

Apoptosis; Caspase; Parasite

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/euptox-a.html

Solubility

10 mM in DMSO

Smiles

C/C(C)=C1[C@@]2([H])[C@@](CC(C(C)=C2)=O)([H])[C@@H](C)CC/1=O

Molecular Formula

C15H20O2

Molecular Weight

232.32

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Liao F, et al. Induction and mechanism of HeLa cell apoptosis by 9-oxo‑10, 11-dehydroageraphorone from Eupatorium adenophorum. Oncol Rep. 2015 Apr;33 (4) :1823-7.