KTX-582 intermediate-1
KTX-582 intermediate-1 is an intermediate in the synthesis of KTX-582 (HY-148274) and can be used for ADC preparation. KTX-582 is an IRAK4 degrader and inducer of apoptosis with DC50 of 4 nM and 5 nM for IRAK4 and Ikaros, respectively[1].
Product Specifications
CAS Number
[845508-29-4]
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis
Type
ADC Related
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ktx-582-intermediate-1.html
Purity
98.61
Solubility
10 mM in DMSO
Smiles
CCOC([C@@H](CC1)CC[C@@H]1OS(=O)(C2=CC=C(C=C2)C)=O)=O
Molecular Formula
C16H22O5S
Molecular Weight
326.41
Precautions
H302, H315, H319, H335
References & Citations
[1]Mainolfi, et al. Preparation of heterocycles as IRAK degraders and uses thereof. World Intellectual Property Organization, WO2022147465 A1. 2022-07-07.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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