JTK-101

JTK-101 is a selective HIV inhibitor. JTK-101 selectively reduces HIV-1 mRNA synthesis by inhibiting Tat cofactors, including CDK9 and cyclin T1, thereby suppressing the transcriptional activity of HIV-1. JTK-101 may be used in the field of anti-HIV virus research[1].

Product Specifications

CAS Number

[503048-34-8]

UNSPSC

12352005

Target

CDK; HIV

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/jtk-101.html

Smiles

N#CC1=CC=C(C=C1)CN2CCC(CC2)(OC3=C4C=C(C=CC4=CC=C35)OC)NC5=O

Molecular Formula

C25H23N3O3

Molecular Weight

413.47

References & Citations

[1]Wang X, et al. Potent and selective inhibition of Tat-dependent HIV-1 replication in chronically infected cells by a novel naphthalene derivative JTK-101. Antivir Chem Chemother. 2007;18 (4) :201-11.