Secalciferol

Secalciferol ((24R) -24,25-Dihydroxyvitamin D3) is the major active metabolite of Vitamin D. Secalciferol activates vitamin D receptor (VDR) with an EC50 value of 150 nM. Secalciferol is involved in a wide range of biological functions such as calcium homeostasis, cellular differentiation and proliferation processes, as well as other functions related to the immune system, which is promising for research of rickets, osteomalacia, hypercalcemia and autoimmune disorders[1][2][3][4][5].

Product Specifications

CAS Number

[55721-11-4]

Product Name Alternative

(24R) -24,25-Dihydroxyvitamin D3

UNSPSC

12352211

Hazard Statement

H301+H311, H330, H372

Target

Endogenous Metabolite; VD/VDR

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Secalciferol.html

Purity

99.85

Solubility

DMSO : 100 mg/mL (ultrasonic) |Ethanol : 50 mg/mL (ultrasonic)

Smiles

C=C(CC1)/C(C[C@H]1O)=C\C=C2[C@@]3([H])[C@@](CCC\2)(C)[C@@H]([C@H](C)CC[C@@H](O)C(C)(C)O)CC3

Molecular Formula

C27H44O3

Molecular Weight

416.64

Precautions

H301+H311, H330, H372

References & Citations

[1]Ono T, et al. 24R,25-dihydroxyvitamin D3 promotes bone formation without causing excessive resorption in hypophosphatemic mice[J]. Endocrinology. 1996 Jun;137 (6) :2633-7.|[2]Higashi T, et al. In vitro and in vivo glucuronidation of 24,25-dihydroxyvitamin D3[J]. Steroids. 1999 Oct;64 (10) :715-25.|[3]Bartonkova I, et al. Profiling of Vitamin D Metabolic Intermediates toward VDR Using Novel Stable Gene Reporter Cell Lines IZ-VDRE and IZ-CYP24[J]. Chem Res Toxicol. 2016 Jul 18;29 (7) :1211-22.|[4]Ikezaki S, et al. Influences of long-term administration of 24R, 25-dihydroxyvitamin D3, a vitamin D3 derivative, in rats[J]. J Toxicol Sci. 1999 May;24 (2) :133-9.