Anti-AGPS Purified

AGPS (alkylglycerone phosphate synthase), is an enzyme that catalyzes the second step of ether lipid biosynthesis in which acyl-dihydroxyacetone phosphate (acyl-DHAP) is converted to alkyl-DHAP by addition of a long chain alcohol and removal of a long-chain acid anion. The protein is localized to the inner side of the peroxisomal membrane and requires FAD as a cofactor. Mutations in AGPS gene have been associated with type 3 of rhizomelic chondrodysplasia punctata (RCDP3), and Zellweger syndrome. Higher expression of AGPS was observed in BCR/ABL positive leukemias and it was also described to be associated with higher risk of relapse.

Product Specifications

Certification

RUO

Reactivity

Human

Immunogen

Recombinant human AGPS (amino acids 158-384)

Target Antigen

AGPS

Clone

AGPS-03

Applications

WB, FC-IC

Concentration

1 mg/mL

Format

Purified

Buffer

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

References & Citations

*Yan Y, He J, Cheng W: Screening of diagnostic biomarkers for ferroptosis-related osteoarthritis and construction of a risk-prognosis model. Ann Med Surg (Lond) . 2024 Jan 4;86 (2) :856-866., URL: https://pubmed.ncbi.nlm.nih.gov/38333254/

Other References

*Itzkovitz B, Jiralerspong S, Nimmo G, Loscalzo M, Horovitz DD, Snowden A, Moser A, Steinberg S, Braverman N: Functional characterization of novel mutations in GNPAT and AGPS, causing rhizomelic chondrodysplasia punctata (RCDP) types 2 and 3. Hum Mutat. 2012 Jan;33 (1) :189-97, URL: http://www.ncbi.nlm.nih.gov/pubmed/21990100, , *Grimm MO, Kuchenbecker J, Rothhaar TL, Grösgen S, Hundsdörfer B, Burg VK, Friess P, Müller U, Grimm HS, Riemenschneider M, Hartmann T: Plasmalogen synthesis is regulated via alkyl-dihydroxyacetonephosphate-synthase by amyloid precursor protein processing and is affected in Alzheimer's disease. J Neurochem. 2011 Mar;116 (5) :916-25., URL: http://www.ncbi.nlm.nih.gov/pubmed/21214572, , *Bhojwani D, Kang H, Menezes RX, Yang W, Sather H, Moskowitz NP, Min DJ, Potter JW, Harvey R, Hunger SP, Seibel N, Raetz EA, Pieters R, Horstmann MA, Relling MV, den Boer ML, Willman CL, Carroll WL: Gene expression signatures predictive of early response and outcome in high-risk childhood acute lymphoblastic leukemia: A children's oncology group study. J Clin Oncol. 2008 Sep 20;26 (27) :4376-84., URL: https://pubmed.ncbi.nlm.nih.gov/18802149/, *Yeoh EJ, Ross ME, Shurtleff SA, Williams WK, Patel D, Mahfouz R, Behm FG, Raimondi SC, Relling MV, Patel A, Cheng C, Campana D, Wilkins D, Zhou X, Li J, Liu H, Pui CH, Evans WE, Naeve C, Wong L, Downing JR: Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling. Cancer Cell. 2002 Mar;1 (2) :133-43., URL: https://pubmed.ncbi.nlm.nih.gov/12086872/

Storage Conditions

Store at 2-8°C. Do not freeze.

Specificity

The mouse monoclonal antibody AGPS-03 recognizes AGPS (alkykglycerone phosphate synthase), an intracellular peroxisomal enzyme important for lipid biosynthesis.