CES2-IN-1

CES2-IN-1 (Compound 24) is a reversible and selective CES2 inhibitor (IC50: 6.72 μM for human CES2) . CES2-IN-1 reduces the level of CES2 in living cells. CES2-IN-1 is effective against Irinotecan (HY-16562) -induced delayed diarrhea and DSS-induced ulcerative colitis[1].

Product Specifications

CAS Number

[2994634-52-3]

UNSPSC

12352005

Target

Carboxylesterase (CES)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hces2-in-1.html

Purity

98.18

Solubility

DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

ClC1=CC=CC2=C1N=C(C=C2)NC3=NC4=CC=CC=C4N3

Molecular Formula

C16H11ClN4

Molecular Weight

294.74

References & Citations

[1]Cao Z, et al. Discovery of novel carboxylesterase 2 inhibitors for the treatment of delayed diarrhea and ulcerative colitis. Biochem Pharmacol. 2023 Sep;215:115742.