Hel 13-5

Hel 13-5 is a monomeric synthetic peptide based on the N-terminal segment of human SP-B. Hel 13-5 mainly is a-helical and consists of 13 hydrophobic and 5 hydrophilic amino acid residues. Hel 13-5 can be used in combination with phospholipids for developing pulmonary surfactant model systems[1][2].

CC(C)C[C@@H](C(O)=O)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@H](CCCCN)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@H](CCCCN)NC([C@H](CC(C)C)NC([C@@H](NC([C@H](CC(C)C)NC([C@H](CCCCN)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@H](CCCCN)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@@H](N)CCCCN)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC1=CNC2=CC=CC=C12)=O)=O)=O)=O)=O)=O)=O)=O

[1]Nakahara H, et al. Pulmonary surfactant model systems catch the specific interaction of an amphiphilic peptide with anionic phospholipid. Biophys J. 2009 Feb 18;96(4):1415-29.|[2]Nakahara H, et al. Langmuir monolayer of artificial pulmonary surfactant mixtures with an amphiphilic peptide at the air/water interface: comparison of new preparations with surfacten (Surfactant TA). Langmuir. 2008 Apr 1;24(7):3370-9.