VK-II-36

VK-II-36 is a carvedilol analog that suppresses sarcoplasmic reticulum Ca2+release but does not block the β-receptor.VK-II-36 inhibits triggered activities evoked by both early and delayed after depolarizations[1].

Product Specifications

CAS Number

[955371-66-1]

UNSPSC

12352005

Hazard Statement

H302

Target

Calcium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/vk-ii-36.html

Purity

99.63

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1N(CCOC2=CC=CC=C2OC)CC(COC3=CC=CC(N4)=C3C5=C4C=CC=C5)OC1

Molecular Formula

C26H26N2O5

Molecular Weight

446.50

Precautions

P264-P270-P330-P501

References & Citations

[1]Maruyama M, et al. Carvedilol analogue inhibits triggered activities evoked by both early and delayed afterdepolarizations. Heart Rhythm. 2013 Jan;10 (1) :101-7.