VK-II-36
VK-II-36 is a carvedilol analog that suppresses sarcoplasmic reticulum Ca2+release but does not block the β-receptor.VK-II-36 inhibits triggered activities evoked by both early and delayed after depolarizations[1].
Product Specifications
CAS Number
[955371-66-1]
UNSPSC
12352005
Hazard Statement
H302
Target
Calcium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/vk-ii-36.html
Purity
99.63
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1N(CCOC2=CC=CC=C2OC)CC(COC3=CC=CC(N4)=C3C5=C4C=CC=C5)OC1
Molecular Formula
C26H26N2O5
Molecular Weight
446.50
Precautions
P264-P270-P330-P501
References & Citations
[1]Maruyama M, et al. Carvedilol analogue inhibits triggered activities evoked by both early and delayed afterdepolarizations. Heart Rhythm. 2013 Jan;10 (1) :101-7.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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