Angiopeptin (TFA)

Angiopeptin TFA, a cyclic octapeptide analogue of somatostatin, is a weak sst2/sst5 receptor partial agonist with IC50 values of 0.26 nM and 6.92 nM, respectively. Angiopeptin TFA is a potent inhibitor of growth hormone release and insulin-like growth factor-1 (IGF-1) production. Angiopeptin TFA inhibits adenylate cyclase or stimulates extracellular acidification. Angiopeptin TFA has the potential for coronary atherosclerosis research[1][2].

Product Specifications

CAS Number

[2478421-60-0]

UNSPSC

12352209

Target

Adenylate Cyclase; Somatostatin Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/angiopeptin-tfa.html

Purity

99.01

Solubility

H2O : 10 mg/mL (ultrasonic)

Smiles

C[C@@H](O)[C@@H](C(N)=O)NC([C@H](CS)NC([C@H](C(C)C)NC([C@H](CCCCN)NC([C@@H](CC1=CNC2=C1C=CC=C2)NC([C@H](CC3=CC=C(O)C=C3)NC([C@H](CS)NC([C@@H](CC4=CC=C5C=CC=CC5=C4)N)=O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O

Molecular Formula

C58H73F6N11O14S2

Molecular Weight

1326.39

References & Citations

[1]Lundergan CF, et al. Peptide inhibition of myointimal proliferation by angiopeptin, a somatostatin analogue. J Am Coll Cardiol. 1991;17 (6 Suppl B) :132B-136B.|[2]Alderton F, et al. Somatostatin receptor-mediated arachidonic acid mobilization: evidence for partial agonism of synthetic peptides. Br J Pharmacol. 2001;132 (3) :760-766.