Propofol

Propofol potently and directly activates GABAA receptor and inhibits glutamate receptor mediated excitatory synaptic transmission. Propofol has antinociceptive properties and is used for sedation and hypnotic[1].

Product Specifications

CAS Number

[2078-54-8]

Product Name Alternative

2,6-Diisopropylphenol

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite; GABA Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/propofol.html

Concentration

10mM

Purity

99.52

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 0.5 mg/mL (ultrasonic)

Smiles

OC1=C(C(C)C)C=CC=C1C(C)C

Molecular Formula

C12H18O

Molecular Weight

178.27

Precautions

H302, H315, H319, H335

References & Citations

[1]R Nadeson, et al. Antinociceptive Properties of Propofol: Involvement of Spinal Cord Gamma-Aminobutyric acid (A) Receptors. J Pharmacol Exp Ther . 1997 Sep;282 (3) :1181-6.