Fluxapyroxad

Fluxapyroxad is a synthetic broad-spectrum fungicide for the control of fungal diseases. Fluxapyroxad inhibits succinate dehydrogenase in complex II of the mitochondrial respiratory chain, resulting in inhibition of spore germination, germ tubes and mycelia growth within the fungus target species[1].

Product Specifications

CAS Number

[907204-31-3]

UNSPSC

12352005

Hazard Statement

H351, H362, H410

Target

Antibiotic; Cytochrome P450; Fungal; Succinate Dehydrogenase

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/fluxapyroxad.html

Concentration

10mM

Purity

99.96

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C(C1=CN(C)N=C1C(F)F)NC2=CC=CC=C2C3=CC(F)=C(F)C(F)=C3

Molecular Formula

C18H12F5N3O

Molecular Weight

381.30

Precautions

H351, H362, H410

References & Citations

[1]Chen X, et al. Effective Monitoring of Fluxapyroxad and Its Three Biologically Active Metabolites in Vegetables, Fruits, and Cereals by Optimized QuEChERS Treatment Based on UPLC-MS/MS. J Agric Food Chem. 2016 Nov 23;64 (46) :8935-8943. |[2]Cao Y, et al., Fluxapyroxad induces chronic colonic inflammation via inhibiting intestinal aryl hydrocarbon receptors in mice. Sci Total Environ. 2025 Apr 10;973:179134.|[3]Chen X, et al., Fluxapyroxad disrupt erythropoiesis in zebrafish (Danio rerio) embryos. Ecotoxicol Environ Saf. 2022 Dec 1;247:114259.|[4]Bénit P, et al., Evolutionarily conserved susceptibility of the mitochondrial respiratory chain to SDHI pesticides and its consequence on the impact of SDHIs on human cultured cells. PLoS One. 2019 Nov 7;14 (11) :e0224132.