NPD4928

NPD4928, a GPX4 inhibitor, enhances RSL3 (HY-100218A) -dependent ferroptosis. NPD4928 binds to ferroptosis suppressor protein 1 (FSP1) and inhibits its enzymatic activity[1].

Product Specifications

CAS Number

[956965-61-0]

UNSPSC

12352005

Target

Ferroptosis; Glutathione Peroxidase

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/npd4928.html

Purity

99.48

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1OC2=C(C(C)=C1C)C(OCC(NCCC3=CNC4=C3C=C(OC)C=C4)=O)=CC5=C2CCC(C)(C)O5

Molecular Formula

C29H32N2O6

Molecular Weight

504.57

References & Citations

[1]Hiromasa Yoshioka, et al. Identification of a Small Molecule That Enhances Ferroptosis via Inhibition of Ferroptosis Suppressor Protein 1 (FSP1) . ACS Chem Biol. 2022 Feb 18;17 (2) :483-491.