Estradiol-d5

Estradiol-d5 is deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway[1][2][3].

Product Specifications

CAS Number

[221093-45-4]

Product Name Alternative

β-Estradiol-d5; 17β-Estradiol-d5; 17β-Oestradiol-d5

UNSPSC

12352005

Hazard Statement

H225, H302+H312+H332, H319

Target

Endogenous Metabolite; Estrogen Receptor/ERR

Type

Isotope-Labeled Compounds

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology; Cancer

Purity

99.73

Solubility

10 mM in DMSO|Ethanol : 20mg/mL (ultrasonic)

Smiles

C[C@]1(CC2)[C@](CC([2H])([2H])[C@]1([2H])O)([H])[C@@](CCC3=C4[2H])([H])[C@@]2([H])C3=CC([2H])=C4O

Molecular Formula

C18H19D5O2

Molecular Weight

277.41

Precautions

H225, H302+H312+H332, H319

References & Citations

[1]Harburger LL, et al. Dose-dependent effects of post-training estradiol plus progesterone treatment on object memory consolidation and hippocampal extracellular signal-regulated kinase activation in young ovariectomized mice. Neuroscience. 2009;160 (1) :6-12.|[2]Mermelstein PG, et al. Estradiol reduces calcium currents in rat neostriatal neurons via a membrane receptor. J Neurosci. 1996 Jan 15;16 (2) :595-604.|[3]Quanfu Huang, et al. 17β-estradiol Upregulates IL6 Expression Through the ERβ Pathway to Promote Lung Adenocarcinoma Progression. J Exp Clin Cancer Res. 2018 Jul 3;37 (1) :133.|[4]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[5]Woolley CS, et al. Estradiol increases the sensitivity of hippocampal CA1 pyramidal cells to NMDA receptor-mediated synaptic input: correlation with dendritic spine density. J Neurosci. 1997 Mar 1;17 (5) :1848-59.|[6]Woolley CS, et al. Estradiol mediates fluctuation in hippocampal synapse density during the estrous cycle in the adult rat. J Neurosci. 1992 Jul;12 (7) :2549-54.|[7]Woolley CS, et al. Roles of estradiol and progesterone in regulation of hippocampal dendritic spine density during the estrous cycle in the rat. J Comp Neurol. 1993 Oct 8;336 (2) :293-306.