Mesembrine

Mesembrine ((+) -Mesembrine) a main alkaloid that features an aryloctahydroindole skeleton. Mesembrine is a 5-HT transporter inhibitor with a Ki of 1.4 nM. Mesembrine also inhibits phosphodiesterase 4B (PDE4B) with an IC50 of 7.8 μM[1][2].

Product Specifications

CAS Number

[468-53-1]

Product Name Alternative

(+) -Mesembrine

UNSPSC

12352005

Target

5-HT Receptor; Phosphodiesterase (PDE)

Type

Natural Products

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/mesembrine.html

Solubility

10 mM in DMSO

Smiles

O=C1CC[C@]2(C3=CC=C(OC)C(OC)=C3)CCN(C)[C@]2([H])C1

Molecular Formula

C17H23NO3

Molecular Weight

289.37

References & Citations

[1]John L Krstenansky. Mesembrine alkaloids: Review of their occurrence, chemistry, and pharmacology. J Ethnopharmacol. 2017 Jan 4;195:10-19.|[2]Golo M J Meyer, et al. GC-MS, LC-MS (n), LC-high resolution-MS (n), and NMR studies on the metabolism and toxicological detection of mesembrine and mesembrenone, the main alkaloids of the legal high "Kanna" isolated from Sceletium tortuosum. Anal Bioanal Chem. 2015 Jan;407 (3) :761-78.