AZD8309

AZD8309 is an orally active antagonist of CXCR2. AZD8309 has the ability to regulate the transmigration of neutrophils. AZD8309 can be used in the study of inflammatory diseases[1].

Product Specifications

CAS Number

[333742-48-6]

UNSPSC

12352005

Target

CXCR

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/azd8309.html

Purity

99.98

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C1SC2=C(N=C(N=C2N1)SCC3=CC=CC(F)=C3F)N[C@@H](CO)C

Molecular Formula

C15H14F2N4O2S2

Molecular Weight

384.42

References & Citations

[1]Malla SR, et al. Effect of oral administration of AZD8309, a CXCR2 antagonist, on the severity of experimental pancreatitis. Pancreatology. 2016 Sep-Oct;16 (5) :761-9. |[2]Walters I, Austin C, Austin R, et al. Evaluation of a series of bicyclic CXCR2 antagonists. Bioorg Med Chem Lett. 2008;18 (2) :798-803.