FLT3-IN-27

FLT3-IN-27 (compound 49) is a FLT3-ITD inhibitor with the IC50 of 174 nM. FLT3-IN-27 inhibits cell growth and increases the number of cells in the G1 phase of the cell cycle and can be used for study of acute myeloid leukemia[1].

Product Specifications

UNSPSC

12352005

Target

FLT3

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/flt3-in-27.html

Smiles

O=C(NC1=NN=C(SC2=C3C(OC(C4=CC=CC=C4)=C3)=NC=N2)S1)NC5=CC=C(OC)C=C5

Molecular Formula

C22H16N6O3S2

Molecular Weight

476.53

References & Citations

[1]Moradi M, et al. Identification of furo[2,3-d]pyrimidin-4-ylsulfanyl-1,3,4-thiadiazole derivatives as novel FLT3-ITD inhibitors. Eur J Med Chem. 2024 Oct 12;280:116962.