Chlorpropamide

Chlorpropamide is an oral hypoglycemic agent that can influence acetaldehyde metabolism in mice and has a potentiating effect on antidiuretic hormone[1][2][3][4].

Product Specifications

CAS Number

[94-20-2]

UNSPSC

12352005

Hazard Statement

H302, H361

Target

Na+/K+ ATPase

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Field of Research

Endocrinology; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/Chlorpropamide.html

Purity

99.79

Solubility

DMSO : ≥ 100 mg/mL|H2O : < 0.1 mg/mL

Smiles

O=S(C1=CC=C(Cl)C=C1)(NC(NCCC)=O)=O

Molecular Formula

C10H13ClN2O3S

Molecular Weight

276.74

Precautions

H302, H361

References & Citations

[1]E Kusano, et al. Chlorpropamide action on renal concentrating mechanism in rats with hypothalamic diabetes insipidus. J Clin Invest. 1983 Oct;72 (4) :1298-313.|[2]A Clark, et al. Islet changes induced by hyperglycemia in rats. Effect of insulin or chlorpropamide therapy. Diabetes. 1982 Apr;31 (4 Pt 1) :319-25.|[3]Abraham A.A. Osinubi, et al. EFFECTS OF VERNONIA AMYGDALINA AND CHLORPROPAMIDE ON BLOOD GLUCOSE. Medical Journal of Islamic World Academy of Sciences. 16:3, 115-119.|[4]R G Little, et al. Effect of tolbutamide and chlorpropamide on acetaldehyde metabolism in two inbred strains of mice. Toxicol Appl Pharmacol. 1985 Sep 15;80 (2) :206-14.