CPD-10
CPD-10 is a potent CCND1 and CDK4 PROTAC degrader. CPD-10 shows anti-proliferation. CPD-10 induces apoptosis. CPD-10 decreases the protein expression of cyclin D1, cyclin D3, CDK4, P-Rb (5807/811) in a dose-dependent manner. (Pink: ligand for target protein (HY-50767) ; black: linker (HY-22391) ; Blue: E3 ligase ligand (HY-168667) ) [1].
Product Specifications
CAS Number
[3055471-57-0]
UNSPSC
12352211
Target
Apoptosis; CDK; PROTACs
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cpd-10.html
Purity
96.69
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=C(NC)N=C1NCCCCCCCNC(CN2CCN(CC2)C3=CN=C(NC4=NC(N(C5CCCC5)C(C(C(C)=O)=C6C)=O)=C6C=N4)C=C3)=O)NC7=NN=C(N(C)C)C=C7
Molecular Formula
C46H61N15O4
Molecular Weight
888.07
References & Citations
[1]Jing Liu, et al. Compounds and methods of treating cancers. French, WO2024183798A1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK4
Available Sizes
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