Edoxaban

Edoxaban (DU-176b) is an orally active, highly potent, selective, and direct Factor Xa (FXa) inhibitor with Ki values of 0.561 and 2.98 nM for free human FXa and prothrombinase. Edoxaban exhibits more than 10,000-fold selectivity over other coagulation proteases. Edoxaban can be used in preventing thromboembolic disease research[1].

Product Specifications

CAS Number

[480449-70-5]

Product Name Alternative

DU-176

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Factor Xa; Thrombin

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/edoxaban.html

Purity

99.81

Solubility

DMSO : 10 mg/mL (ultrasonic)

Smiles

O=C(N(C)C)[C@@H](CC1)C[C@H]([C@H]1NC(C(NC(C=C2)=NC=C2Cl)=O)=O)NC(C3=NC(CC4)=C(CN4C)S3)=O

Molecular Formula

C24H30ClN7O4S

Molecular Weight

548.06

Precautions

H302, H315, H319, H335

References & Citations

[1]Furugohri T, et al. DU-176b, a potent and orally active factor Xa inhibitor: in vitro and in vivo pharmacological profiles. J Thromb Haemost. 2008 Sep;6 (9) :1542-9.