GAC0003A4
GAC0003A4 is an LXR inverse agonist that inhibits LXR transcriptional activity. GAC0003A4 also efficiently degrades LXRβ protein. GAC0003A4 has the potential to be used in advanced pancreatic cancer and other refractory malignancies[1].
Product Specifications
CAS Number
[929492-71-7]
UNSPSC
12352005
Target
LXR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gac0003a4.html
Purity
98.94
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(N1CCN(CC1)C2=C(C)C=CC=C2)C3=CC(OC)=CC(OC)=C3
Molecular Formula
C20H24N2O3
Molecular Weight
340.42
References & Citations
[1]Karaboga H, et al. Screening of Focused Compound Library Targeting Liver X Receptors in Pancreatic Cancer Identified Ligands with Inverse Agonist and Degrader Activity. ACS Chem Biol. 2020 Nov 20;15 (11) :2916-2928.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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