TASP0415914

TASP0415914 is a potent and orally active PI3Kγ inhibitor with an IC50 of 29 nM. TASP0415914 also shows potent Akt inhibitory activities with an IC50 of 294 nM. TASP0415914 can be used for inflammatory diseases research[1].

Product Specifications

CAS Number

[1292300-75-4]

UNSPSC

12352005

Target

Akt; PI3K

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/tasp0415914.html

Purity

99.02

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

CC(NC1=NC(C)=C(C2=NC(N3CC(O)CCC3)=NO2)S1)=O

Molecular Formula

C13H17N5O3S

Molecular Weight

323.37

References & Citations

[1]Yusuke Oka, et al. Discovery of N-{5-[3- (3-hydroxypiperidin-1-yl) -1,2,4-oxadiazol-5-yl]-4-methyl-1,3-thiazol-2-yl}acetamide (TASP0415914) as an orally potent phosphoinositide 3-kinase γ inhibitor for the treatment of inflammatory diseases. Bioorg Med Chem. 2013 Dec 15;21 (24) :7578-83.