PH-Low Insertion Peptide

PH-Low Insertion Peptide (pHLIP) is a short, pH-responsive peptide capable of inserting across a cell membrane to form a transmembrane helix at acidic pH. pH-Low Insertion Peptide targets the acidic tumor microenvironment for tumors at early and metastatic stages with high specificity, used as a specific ligand. pH-Low Insertion Peptide successfully modify polylysine polymers to have the pH-responsive capability. pH-Low Insertion Peptide-based targeting of cancer presents an opportunity to monitor metabolic changes, and to selectively deliver imaging and therapeutic agents to tumors[1][2][3].

Product Specifications

CAS Number

[2293160-09-3]

Product Name Alternative

PHLIP

UNSPSC

12352209

Target

Others

Type

Peptides

Related Pathways

Others

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/ph-low-insertion-peptide.html

Purity

98.35

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

[Ala-Cys-Glu-Gln-Asn-Pro-Ile-Tyr-Trp-Ala-Arg-Tyr-Ala-Asp-Trp-Leu-Phe-Thr-Thr-Pro-Leu-Leu-Leu-Leu-Asp-Leu-Ala-Leu-Leu-Val-Asp-Ala-Asp-Glu-Thr]

Molecular Formula

C189H282N42O55S

Molecular Weight

4054.56

References & Citations

[1]Yushuang Wei, et al. pH-responsive pHLIP (pH low insertion peptide) nanoclusters of superparamagnetic iron oxide nanoparticles as a tumor-selective MRI contrast agent. Acta Biomater. 2017 Jun;55:194-203.|[2]Adochite RC, et al. Targeting breast tumors with pH (low) insertion peptides[J]. Mol Pharm. 2014 Aug 4;11 (8) :2896-905.|[3]Svoronos AA, et al. Tumor-Targeted, Cytoplasmic Delivery of Large, Polar Molecules Using a pH-Low Insertion Peptide[J]. Mol Pharm. 2020 Feb 3;17 (2) :461-471.