H mgB1/H mg-1

High mobility group protein B1 is a member of the H mgB family consisting of three members, H mgB1, H mgB2 and H mgB3.It Contains 2 H mg box DNA-binding domains entitled box A and box B and It is a highly negative-charged C terminus. As a nuclear protein, H mgB1 stabilizes nucleosomes and allows bending of DNA that facilitates gene transcription which is essential for individual survival. Meanwhile, it is revealed that H mgB1 can also act as a cytokine extracellularlly and regulates monocyte, T cell, dendritic cell activities in inflammatory responses.