Araloside A

Araloside A (Chikusetsusaponin IV), triterpenoid saponins, is an orally active component of Aralia elata. Araloside A shows low-renin-inhibitory activity with an IC50 of 77.4 μM. Araloside A can inhibit cell proliferation and induce apoptosis. Araloside A suppresses inflammatory cytokines IL-1β and IL-6 production. Araloside A can be used for the researches of cancer, inflammation and cardiovascular disease, such as renal cell carcinoma and rheumatoid arthritis[1][2][3][4].

Product Specifications

CAS Number

[7518-22-1]

Product Name Alternative

Chikusetsusaponin IV

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Bcl-2 Family; Interleukin Related; Renin

Type

Natural Products

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer; Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/araloside-a.html

Purity

99.86

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C([C@]1(CCC(C)(C)C2)[C@]2([H])C3=CC[C@@]4([H])[C@@](C)(CC[C@]5([H])[C@@]4(CC[C@H](O[C@]([C@@H]([C@@H](O)[C@@H]6O[C@]7([H])O[C@@H](CO)[C@H](O)[C@H]7O)O)([H])O[C@@H]6C(O)=O)C5(C)C)C)[C@]3(C)CC1)O[C@@H]([C@@H]([C@@H](O)[C@@H]8O)O)O[C@@H]8CO

Molecular Formula

C47H74O18

Molecular Weight

927.08

Precautions

H302, H315, H319, H335

References & Citations

[1]Takahashi S, et al. Inhibition of human renin activity by saponins. Biomed Res. 2010 Apr;31 (2) :155-9.|[2]Liu Y, et.al. The antitumor effects of Araloside A extracted from the root bark of Aralia elata on human kidney cancer cell lines. African Journal of Pharmacy and Pharmacology Vol. 5 (4), pp. 462-467, April 2011. |[3]Ding Y, et.al. Pro-apoptotic and anti-inflammatory effects of araloside A on human rheumatoid arthritis fibroblast-like synoviocytes. Chem Biol Interact. 2019 Jun 1;306:131-137.|[4]He H, et al. Gastroprotective effect of araloside A on ethanol- and aspirin-induced gastric ulcer in mice: involvement of H+/K+-ATPase and mitochondrial-mediated signaling pathway. J Nat Med. 2019 Mar;73 (2) :339-352.