REST antibody
Product Specifications
Background
Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression.
Synonyms
RE1-silencing transcription factor|Neural-restrictive silencer factor|X2 box repressor|REST|NRSF|XBR
Gene ID
5978
UniProt
Q13127
Host
Rabbit
Reactivity
Human, Rat
Immunogen
RE1-silencing transcription factor
Target
REST
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IP
Field of Research
Stem Cells, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:1000; IP: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
122 kDa, 200kd
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IP
Curated Selection
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