RAN antibody
Product Specifications
Background
GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity) . The complex with BIRC5/ survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2. Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases.
Synonyms
GTP-binding nuclear protein Ran|Androgen receptor-associated protein 24|GTPase Ran|Ras-like protein TC4|Ras-related nuclear protein|RAN|ARA24
Gene ID
5901
UniProt
P62826
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
RAN, member RAS oncogene family
Target
RAN
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IHC, IF, IP, WB
Field of Research
Epigenetics, Signal Transduction, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200; IF: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
24 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, IHC, IF, IP, WB
Immunogen Sequence
1-216aa
Curated Selection
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