CDKN2A antibody
Product Specifications
Background
CDKN2A generates several transcript variants which differ in their first exons. At least three alternatively-spliced variants encoding distinct proteins have been reported, and two are related, named p16-INK4 and p14 respetively, sharing 50% identity. The third one is completely stuctually un-related, called p14 (ARF) or p19 (ARF) . FNab06064 reacted with p16 specifically. P16 plays an important role in regulating the cell cycle, and mutations in p16 increase the risk of developing a variety of cancers, notably melanoma.
Synonyms
Cyclin-dependent kinase inhibitor 2A|Cyclin-dependent kinase 4 inhibitor A (CDK4I) |Multiple tumor suppressor 1 (MTS-1) |p16-INK4a (p16-INK4, p16INK4A) |CDKN2A|CDKN2|MTS1
Gene ID
1029
UniProt
P42771
Host
Rabbit
Reactivity
Human
Immunogen
Cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
Target
CDKN2A
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IF, IP, IHC, FC
Field of Research
Metabolism, Immunology, Cell Division and Proliferation, Cancer
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:5000; IP: 1:500-1:5000; IHC: 1:50-1:500; IF: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
16-18 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IF, IP, IHC, FC
Immunogen Sequence
1-156aa
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