LNX1 antibody
Product Specifications
Background
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65 (By similarity) . Isoform 2 provides an endocytic scaffold for IGSF5/JAM4.
Synonyms
E3 ubiquitin-protein ligase LNX|Ligand of Numb-protein X 1|Numb-binding protein 1|PDZ domain-containing RING finger protein 2|RING-type E3 ubiquitin transferase LNX|LNX1|LNX|PDZRN2
Gene ID
84708
UniProt
Q8TBB1
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Ligand of numb-protein X 1
Target
LNX1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Epigenetics, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
70 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB
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