IVNS1ABP antibody
Product Specifications
Background
Plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. Protects cells from cell death induced by actin destabilization; Protects neurons from dendritic spines and actin filaments damage induced by the actin-destabilizing cytochalasin B when overexpressed. Activates Erk signaling pathway when overexpressed in cultured cell lines (By similarity) . May be a component of the cellular splicing machinery with a role in pre-mRNA splicing; may mediate the inhibition of splicing by NS/influenza virus NS1A protein. Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription.
Synonyms
Influenza virus NS1A-binding protein (NS1-BP, NS1-binding protein) |Aryl hydrocarbon receptor-associated protein 3|Kelch-like protein 39|IVNS1ABP|ARA3|FLARA3|KIAA0850|KLHL39|NS1|NS1BP
Gene ID
10625
UniProt
Q9Y6Y0
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Influenza virus NS1A binding protein
Target
IVNS1ABP
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Neuroscience, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
70 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC
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