KRT18 antibody
Product Specifications
Background
Keratins are a large family of proteins that form the intermediate filament cytoskeleton of epithelial cells, which are classified into two major sequence types. Type I keratins are a group of acidic intermediate filament proteins, including K9–K23, and the hair keratins Ha1–Ha8. Type II keratins are the basic or neutral courterparts to the acidic type I keratins, including K1–K8, and the hair keratins, Hb1–Hb6. KRT18, also named as CYK18, PIG46 and K18, is the most commonly found members of the intermediate filament gene family. KRT18 is a type I keratin which is found primarily in non squamous epithelia and is present in a majority of adenocarcinomas and ductal carcinomas but not in squamous cell carcinomas.
Synonyms
Keratin, type I cytoskeletal 18|Cell proliferation-inducing gene 46 protein|Cytokeratin-18 (CK-18) |Keratin-18 (K18) |KRT18|CYK18
Gene ID
3875
UniProt
P05783
Host
Mouse
Reactivity
Human, Mouse, Rat
Immunogen
Keratin 18
Target
KRT18
Clonality
Monoclonal
Isotype
IgG2a
Applications
ELISA, WB, FC, IF, IHC
Field of Research
Cancer, Immunology, Cardiovascular
Purification
Protein A+G purification
Dilution
WB: 1:5000-1:30000; IHC: 1:500-1:1000; IF: 1:100-1:300
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
48 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Clone ID
6E3
Tested Applications
ELISA, WB, FC, IF, IHC
Immunogen Sequence
127-430aa
Curated Selection
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