CDK4 antibody
Product Specifications
Background
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported.
Synonyms
Cyclin-dependent kinase 4|Cell division protein kinase 4|PSK-J3|CDK4
Gene ID
1019
UniProt
P11802
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
cyclin-dependent kinase 4
Target
CDK4
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IF
Field of Research
Metabolism, Immunology, Signal Transduction, Cell Division and Proliferation
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:20 - 1:100
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
32 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
CAS Number
9007-83-4
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
36339141 1x10<sup>6</sup> cells/1.0ml
PDS5B CRISPR Knock Out 293T Cell Line (Human)
Ask
View Details