TGR5 agonist 5
TGR5 agonist 5 (compound K91) is a potent agonist of TGR5, with EC50s of 19 μM and 30 μM in CRE-Luciferase assay anf cAMP accumulation assay, respectively[1].
Product Specifications
UNSPSC
12352005
Target
G protein-coupled Bile Acid Receptor 1
Type
Reference compound
Related Pathways
GPCR/G Protein
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/tgr5-agonist-5.html
Smiles
CC1(C)N(CC(NC[C@H]2OC3=CC=CC=C3C2)=O)CCC4=CC=CC=C41
Molecular Formula
C22H26N2O2
Molecular Weight
350.45
References & Citations
[1]M Giovanna E Papadopoulos, et al. Discovery and characterization of small-molecule TGR5 ligands with agonistic activity. Eur J Med Chem. 2024 Jun 28:276:116616.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-161817/TGR5-agonist-5-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-161817/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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