BMI1 antibody
Product Specifications
Background
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.
Synonyms
Polycomb complex protein BMI-1|Polycomb group RING finger protein 4|RING finger protein 51|BMI1|PCGF4|RNF51
Gene ID
648
UniProt
P35226
Host
Mouse
Reactivity
Human, Mouse
Immunogen
BMI1 polycomb ring finger oncogene
Target
BMI1
Clonality
Monoclonal
Isotype
IgG1
Applications
ELISA, WB, IHC, IF, IP
Field of Research
Epigenetics, Metabolism, Cancer, Developmental biology, Stem Cells, Cell Division and Proliferation
Purification
Protein A+G purification
Dilution
WB: 1:500-1:2000; IP: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:10-1:100
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
37 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Clone ID
8D5
Tested Applications
ELISA, WB, IHC, IF, IP
Immunogen Sequence
1-326aa
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