AP3B1 antibody
Product Specifications
Background
Subunit of non-clathrin-and clathrin-associated adaptor protein complex 3(AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network(TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.
Synonyms
AP-3 complex subunit beta-1|Adaptor protein complex AP-3 subunit beta-1|Adaptor-related protein complex 3 subunit beta-1|Beta-3A-adaptin|Clathrin assembly protein complex 3 beta-1 large chain|AP3B1|ADTB3A
Gene ID
8546
UniProt
O00203
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
adaptor-related protein complex 3, beta 1 subunit
Target
AP3B1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IF, IP
Field of Research
Signal Transduction, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:5000 IP: 1:200-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
140 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
CAS Number
9007-83-4
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