AKR1C3 antibody

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha, 11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene.

Aldo-keto reductase family 1 member C3|17-beta-hydroxysteroid dehydrogenase type 5 (17-beta-HSD 5)|3-alpha-HSD type II, brain|3-alpha-hydroxysteroid dehydrogenase type 2 (3-alpha-HSD type 2)|Chlordecone reductase homolog HAKRb|Dihydrodiol dehydrogenase 3 (DD-3, DD3)|Dihydrodiol dehydrogenase type I|HA1753|Prostaglandin F synthase (PGFS)|Testosterone 17-beta-dehydrogenase 5|AKR1C3|DDH1|HSD17B5|KIAA0119|PGFS