CKLF1-C19

CKLF1-C19 is the C-terminal peptide of human chemokine-like factor 1 (CKLF1) . CKLF1-C19 interacts with CCR4, and inhibits chemotaxis induced by both CKLF1 and CCL17. CKLF1-C19 can suppress allergic lung inflammation via inhibiting chemotaxis mediated by CCR3 and CCR4[1].

Product Specifications

CAS Number

[960358-79-6]

UNSPSC

12352209

Target

CCR

Type

Peptides

Related Pathways

GPCR/G Protein; Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/cklf1-c19.html

Purity

99.76

Solubility

H2O : ≥ 50 mg/mL

Smiles

O=C([C@H]1N(CCC1)C(CNC([C@H](CO)NC([C@H]2N(CCC2)C([C@H](CC(N)=O)NC([C@@H](N)CC3=CC=CC=C3)=O)=O)=O)=O)=O)N[C@@H](CC4=CC=C(C=C4)O)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N5[C@@H](CCC5)C(N[C@@H](C(C)C)C(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCC(O)=O)C(N[C@@H](C(C)C)C(N[C@H](C(O)=O)CC(C)C)=O)=O)=O)=O)=O)=O)CC6=CN=CN6)=O)=O)=O)=O)=O)=O

Molecular Formula

C103H161N27O28

Molecular Weight

2225.54

References & Citations

[1]Tian L, et al. The CKLF1-C19 peptide attenuates allergic lung inflammation by inhibiting CCR3- and CCR4-mediated chemotaxis in a mouse model of asthma. Allergy. 2011 Feb;66 (2) :287-97.